Preoperative pain of anxiety patients undergoing thoracoscopic lung lesion resection
Conditions
Interventions
C group:Routine general anesthesia induction and maintenance program
SK group:Before the induction of general anesthesia, 0.5 mg/kg of dextral ketamine was diluted to 10 ml with normal saline, and then the routine anesthesia induction scheme was carried out. During the
Sponsors
Department of Anesthesiology, Drum Tower Hospital Affiliated to Nanjing University Medical School
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients who underwent unilateral lung lesion resection under double-hole thoracoscope; 2) Gender unlimited, age 18-64, BMI 18-28kg/m2; 3) Preoperative anxiety, HADS-A = 8 points; 4) American Association of Anesthesiologists (ASA) Class I - II; 5) Join voluntarily and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Those with severe hypertension (resting systolic/diastolic pressure exceeding 180/100 mmHg), intracranial space occupying or intracranial hypertension; 2) Those who have brain injury, cerebral infarction or cerebral hemorrhage recently; Those with severe organ dysfunction; Glaucoma and hyperthyroidism; 3) Previous history of angina pectoris, myocardial infarction or heart failure; 4) Thoracoscopic mediastinum, pleura and other non-pulmonary masses resection; 5) Patients with central nervous system disease; Those who have mental or nervous system diseases, cognitive and language disorders and cannot cooperate to complete the follow-up; 6) Previous history of chest and back surgery or abnormal surgical anesthesia recovery; 7) Those who are allergic to known test drugs; 8) Those who have taken analgesics, anti-anxiety drugs, sleeping pills for a long time or have a history of abuse or dependence of other drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chronic pain incidence and pain score 90 days after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs at different time points (before intubation; during intubation; at skin incision; at the beginning of exploration; at skin suture; when entering PACU; before extubation; when removing the arterial catheter);Dose of anesthetic analgesics and propofol during operation;Time weighted difference of pain score and pain degree within 48h after operation (SPID48) (time points: 3h, 6h, 24h, 48h, and time weighted difference of pain intensity within 3-6h, 6-24h, 24-48h);Preoperative sleep score;Prevalence of preoperative anxiety;The time, type and dose of the first remedy analgesic drug;The time, type and dose of the first time to receive additional remedy analgesics;The number of times and cumulative use of remedial analgesics in 0-24h, 24h - 48h and 0-48h;Inflammation index: IL-6, CRP; Stress and immune indicators: neutrophil extracellular trap net, ACTH, corticosterone, CD3+, CD4+, CD4+/CD8+;Postoperative complications during hospitalization;Clavien-Dindo grading;Anxiety score at 24h and 48h after operation;Delirium at 24h and 48h after operation;Sleep score at 24h and 48h after operation;Pain situation, nature of pain, type and dose of remedial analgesics used 90 days after operation;Intraoperative hypotension, hypertension, number and dose of vasoactive drugs used during operation;New cardiac and cerebrovascular complications during hospitalization;Types and dosage of analgesics used during and after operation;Postoperative adverse reactions;Incidence of chronic pain;Post-discharge outcome; | — |
Countries
China
Contacts
Public ContactZhengliang Ma
Department of Anesthesiology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing 210008, China
Outcome results
None listed