Endometrial injury
Conditions
Interventions
Group of endometrial injury (Exosome perfusion of uterine cavity):None
Sponsors
Shenzhen Maternity & Child Healthcare Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Age 20-45 years old, female, body mass index 1.1ng/ml; 7. The results of TCT examination were normal within one year or the results of TCT and HPV examination were normal within three years; ? With fully informed consent, the patients voluntarily participated in the study and were able to complete the follow-up on schedule.
Exclusion criteria
Exclusion criteria: 1. Any person suffering from serious cardiovascular, lung, liver and kidney diseases; suffering from chronic diseases: diabetes, hypertension, blood diseases, embolic diseases, autoimmune diseases, etc.; having concomitant diseases that seriously endanger the safety of patients or affect the completion of the study; 2. Uncured STI such as AIDS, syphilis, gonococcus or chlamydia, uncured reproductive tract infectious diseases, and uncured alcoholism, drug abuse and drug addiction; 3. Malignant tumors or suspected malignant tumors; 4. The presence of uterine malformations, adenomyosis, uterine fibroids, endometrial hyperplasia and other uterine organic lesions, the presence of hydrosalpinx or ovarian cysts and other reproductive organ lesions; 5. Currently receiving neuropsychiatric medication; 6. Those who were pregnant before inclusion or had sexual life after menstruation; 7. Use of estrogens, progestogens or antibiotics in the past month; 8. Participating in other clinical trials; 9. Patients who did not sign the informed consent; 10. Other conditions determined by the investigator as unsuitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Menstrual diary & Symptom diary;Endometrial thickness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Endometrial receptivity microarray;Endometrial microbiome testing;Detection of endometrial immune cells; | — |
Countries
China
Contacts
Public ContactZheng Zheng
Shenzhen Maternity & Child Healthcare Hospital Ethics Committee of Drugs & Medical Devices Clinical Trials
Outcome results
None listed