Dentition defect
Conditions
Interventions
Group of dentition defect (Guided bone regeneration):No
Sponsors
West China Stomatological Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Aged between 18 and 65 years old (including 18 years old and 65 years old), regardless of gender; 2) Single or multiple missing teeth with Terheyden 1/4~3/4 type labial bone plate defect, requiring GBR; 3) The patient is in good health and can tolerate the operation; 4) Subjects fully understand the benefits and risks of this trial, and are willing to participate and sign informed consent.
Exclusion criteria
Exclusion criteria: 1) Participated in other clinical trials within 4 weeks before the start of this trial; 2) Heart disease (i.e., class II and above heart function disease); liver and kidney dysfunction (ALT, AST > normal value 1.5 times; diabetic patients with poorly controlled blood sugar levels (fasting blood sugar still =8.0 mmol/L after control); 3) Patients with uncontrolled oral diseases, such as progressive periodontitis, severe periapical infection, and severe habitual bruxism; 4) Uncontrolled metabolic diseases such as diabetes, osteochondrosis, thyroid disease, and severe liver and kidney dysfunction; 5) Patients with bone diseases such as osteoporosis, osteomalacia, and osteosclerosis; 6) Various bone defects caused by malignant tumors, active infectious lesions, and metabolic bone diseases during the active period; 7) Patients with systemic infections or acute local infections at the surgical site; 8) Hematological diseases such as aplastic anemia, those who have taken anticoagulant drugs within the past 3 months or whose coagulation test results are not within the normal range; 9) Patients using drugs that may affect soft and hard tissue healing, such as long-term use of sedative hypnotics (continuous use for more than 3 months), long-term use of non-steroidal anti-inflammatory drugs or adrenal cortex hormones (continuous use for more than 3 months), or those who have received drug treatment that may affect or promote bone metabolism within the past 3 months; 10) Patients who smoke heavily (more than 20 cigarettes/day) within the past 6 months and during bone healing; 11) Autoimmune diseases; 12) Undergoing radiotherapy or having received head and neck radiotherapy within one year; 13) Mental illness, drug abuse, alcoholism; 14) Those with a clear history of collagen allergy; 15) Pregnant and lactating women. 16) Other conditions that researchers believe are not suitable for participation in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thickness of the labial bone plate; | — |
Countries
China
Contacts
Public ContactAnchun Mo
West China Hospital of Stomatology
Outcome results
None listed