Acute
Conditions
Interventions
Rivaroxaban group:Rivaroxaban (5 mg St / 10 mg st) + aspirin 300 mg + clopidogrel bisulfate 300 mg or ticagrelor 180 mg
placebo group:Placebo + aspirin 300mg + clopidogrel bisulfate 300mg or ticagrelor 180mg
Sponsors
Yueyang Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age = 18 (2) For the first STEMI, the diagnostic criteria are in accordance with the Guidelines for the Diagnosis and Treatment of Acute ST-segment Elevation Myocardial Infarction, and the following points must be met: ? Ischemic post-sternal pain attack lasts for more than 20-30 minutes; ? ECG has two or more adjacent leads with ST segment elevation (limb lead>0.1mv, precordial lead>0.2mv) or new left bundle branch block; ? With or without serum markers, at least 99% of the reference value; ? See a doctor within 12 hours after the onset of STEMI.
Exclusion criteria
Exclusion criteria: ? Patients who are unable to perform PCI directly and have not opened blood vessels after PCI due to various reasons; ? Patients who cannot be followed up for prognosis due to various reasons; ? The relevant important time node data is inaccurate or incomplete; ? Patients who have undergone thrombolytic therapy; ? Poor basic condition, serious impairment of liver and kidney function, known clinical history of human immunodeficiency virus infection, drug abuse (drug or alcohol), problems in the past 6 months or any serious disease, such as cancer that limits life expectancy to less than 12 months; ? High blood pressure (systolic blood pressure>200mmHg or diastolic blood pressure>120mmHg); ? There are contraindications to anticoagulation (major surgery, biopsy of parenchymal organs or severe trauma, severe anemia, active bleeding, history of stroke in the past three months and other situations that aggravate the risk of bleeding); ? Platelet count is lower than 50 * 109/ul during screening; ? The international standardization ratio higher than 1.5 is known at the time of screening; ? Other anticoagulant drugs, including heparin, low molecular weight heparin, warfarin, have been used before operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| major adverse cardiac events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac related rehospitalization and all-cause death; | — |
Countries
China
Contacts
Public ContactGang Pan
Yueyang Central Hospital
Outcome results
None listed