chronic obstructive pulmonary disease (COPD)
Conditions
Interventions
COPD with high cough sensitivity group:N/A
COPD with low cough sensitivity group:N/A
Sponsors
Shanghai Tongji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years; 2. COPD is diagnosed according to the Global Initiative Criteria for Chronic Obstructive Pulmonary Disease (GOLD2020); Specific standards: (1) A long history of smoking or occupational dust inhalation; (2) Suffering from dyspnea, chronic cough or expectoration; (3) FEV1/FVC value < 0.70 after bronchodilator inhalation; 3. No symptoms of respiratory infection or exacerbation in the 1 month prior to the study; 4. Willing to sign written informed consent and comply with the study protocol.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating patients; 2. Complicated with other lung diseases such as asthma, bronchiectasis, pulmonary interstitial diseases, lung tumors, pulmonary resection, etc.; 3. Complicated with severe cardiac insufficiency, severe liver and kidney dysfunction, mental and cognitive dysfunction, hearing and communication dysfunction, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Minimum inhalation concentration of capsaicin solution corresponding to induced cough >=2 times;Minimum inhalation concentration of capsaicin solution corresponding to induced cough >=5 times; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cough visual analogue scale score;Hull airway reflux questionnaire;Chronic obstructive pulmonary disease assessment test;Modified version of the medical research council dyspnea scale; | — |
Countries
China
Contacts
Public ContactYu Li
Shanghai Tongji Hospital
Outcome results
None listed