Study on the correlation and mechanism between postoperitive delirium and postoperative gut microbiota dysbiosis based on multi-omics method--A nested case-control study

The role of gut microbiota and its metabolites in perioperative neurocognitive dysfunction

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300070477

Enrollment

Unknown

Registered

2023-04-13

Start date

2023-04-13

Completion date

Unknown

Last updated

2023-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperitive delirium (POD)

Interventions

control group:none

postoperative delirium group:none

Eligibility

Sex/Gender

All

Age

60 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for elective off-pump coronary artery bypass grafting. 2. Aged 60 to 80 years. 3. Voluntarily sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with severe liver (child-pugh grade c) or kidney (chronic kidney disease Grade 3-4) dysfunction before surgery. 2. Patients with MMSE<=17 or with a history of dementia and delirium. 3. Patients with severe visual and hearing disabilities can not cooperate with the research. 4. Patients with a history of gastrointestinal surgery or severe chronic gastrointestinal disease. 5. Oral antibiotics for more than 3 days in the last 1 month, and oral probiotics and prebiotics before surgery.

Design outcomes

Primary

Measure	Time frame
a diversity of intestinal flora;ß diversity of intestinal flora;gut microbiota metabolites;	—

Countries

China

Contacts

Public ContactHuang Li'ning

The Second Hospital of Hebei Medical University

15803213730@163.com+86 311 6600 3887

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026