Liver damage caused by antituberculous drugs (ATLI)
Conditions
Interventions
Group of active pulmonary tuberculosis:None
Sponsors
Medical College of Qingdao University
Eligibility
Sex/Gender
All
Age
16 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged from 16 to 85 years were enrolled in DOTS (directly observed treatment short course), and the duration of anti-tuberculosis chemotherapy was less than 1 week; 2. A fixed home address is available for follow-up.
Exclusion criteria
Exclusion criteria: 1. History of liver injury or suspected liver injury upon admission; 2. Suspected multidrug-resistant tuberculosis with extrapulmonary tuberculosis; 3. Patients with severe illness who are likely to die within weeks of the start of treatment; 4. HIV infection; 5. Patients with kidney disease, coronary heart disease, malignant tumor, mental illness or alcoholism; 6. Pregnant and lactating patients; 7. Recent (within one month) trauma, surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antituberculosis drug induced liver injury;The course of ATLI is associated with important events;Serum nutritional indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nutrition and lifestyle behaviour;Clinical manifestations and features of TB;Oxidative stress and immunoinflammatory levels; | — |
Countries
China
Contacts
Public ContactWang Qiuzhen
Qingdao University
Outcome results
None listed