hepatic encephalopathy (HE), portal hypertension
Conditions
Interventions
Clostridium butyricum group:Clostridium butyricum 2 tablets/time 3 times/day
Lactulose 15ml/time, 3 times/day
Lactulose group:Lactulose 15ml/time, 3 times/day
Sponsors
Beijing Youan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years, no gender limit. 2. Patients treated with TIPS for portal hypertension (esophageal fundus variceal bleeding and/or recurrent chest/ascites) with or without cirrhosis. 3. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Previous episodes of hepatic encephalopathy. 2. Mental disorders, cognitive disorders, do not cooperate with the examination. 3. Unable or unwilling to retain stool specimens. 4. Patients with liver cancer and other malignant tumors. 5. Infected people who cannot be controlled. 6. Patients who underwent gastrointestinal surgery 3 months before enrollment. 7. Patients with other digestive tract diseases that may affect the intestinal microecology (such as ulcerative colitis, Crohn's disease, etc.). 8. TIPS or shunt surgery has been performed. 9. TIPS patients with shunt loss after surgery. 10. Pregnant patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hepatic encephalopathy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of occurrence of hepatic encephalopathy;Adverse reaction rate;Transplant free survival;Gut microbiota;Metabolomics;Laboratory outcome;Imaging results; | — |
Countries
China
Contacts
Public ContactLi Jianjun
Beijing Youan Hospital,Capital Medical University
Outcome results
None listed