Stroke, spinal cord injury, brachial plexus injury, acute myocardial infarction
Conditions
Interventions
Subject 1: Observation on effect of rehabilitation intervention for movement disorders based on real world:-
Subject 2:(1) Effectiveness of precise regulation of rTMS combined with upper limb rehabilitation robot in intervention on upper limb dysfunction after cerebral infarction. Test group 1:Individualized
Subject 2:(1) Effectiveness of precise regulation of rTMS combined with upper limb rehabilitation robot in intervention on upper limb dysfunction after cerebral infarction. Test group 2:The low freque
Subject 2:(1) Effectiveness of precise regulation of rTMS combined with upper limb rehabilitation robot in intervention on upper limb dysfunction after cerebral infarction. control group:rTMS pseudost
Subject 2:(2) The effectiveness of cerebellar intermittent theta burst stimulation combined with Tai Chi training in intervention on balance dysfunction after cerebral infarction. Test group 1:The use
Subject 2:(2) The effectiveness of cerebellar intermittent theta burst stimulation combined with Tai Chi training in intervention on balance dysfunction after cerebral infarction. Test group 2:Use cer
Subject 2:(2) The effectiveness of cerebellar intermittent theta burst stimulation combined with Tai Chi training in intervention on balance dysfunction after cerebral infarction. control group:Use ce
Sponsors
Zhongda Hospital affiliated to Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Effectiveness of precise regulation of rTMS combined with upper limb rehabilitation robot in intervention on upper limb dysfunction after cerebral infarction. Inclusion criteria: patients with cerebral infarction diagnosed by computed tomography (CT) and/or MRI; first-time, unilateral onset or previous onset but no neurological dysfunction; stable vital signs; age 40-70 years; The course of the disease is 1 week to 3 months; the upper limbs are paralyzed; the selected participants sign the informed consent. 2) The effectiveness of cerebellar intermittent theta burst stimulation combined with Tai Chi training in intervention on balance dysfunction after cerebral infarction. Inclusion criteria: patients with cerebral infarction diagnosed by computed tomography (CT) and/or MRI; first-time, unilateral onset or previous onset but no neurological dysfunction; stable vital signs; age 40-70 years; The course of the disease is 1 week to 3 months; there is balance dysfunction, and the Berg score is between 21-55; the selected participants sign the informed consent. 3) Effectiveness of multimodal neuromodulation combined with multichannel functional electrical stimulation to assist walking in intervention on walking dysfunction after spinal cord injury. Inclusion criteria: patients with traumatic or non-traumatic incomplete spinal cord injury classified as AIS-C or AIS-D in accordance with ISNCSCI clinical diagnostic criteria; neurological level T6-L2; age 18-65 years old; vital signs stable, The consciousness is clear; the course of disease is 1 to 3 months; I sign the informed consent. 4) Effectiveness of high-power compound spectrum and peripheral functional magnetic stimulation combined with task-oriented training in intervention on peripheral paralysis caused by brachial plexus injury. Inclusion criteria: Brachial plexus injuries caused by various traumas, confirmed by electromyography; age 18-65 years old, male or female; disease duration 1-3 months; no upper limb joint stiffness, dislocation, no muscle ligament contracture; no History of stroke, spinal cord injury, cervical nerve root compression, peripheral nerve entrapment; no diabetes, kidney disease, blood disease, tumor and other systemic diseases affecting peripheral nerve function; I signed the informed consent. 5) Effectiveness of aerobic exercise intervention on exercise tolerance in patients with acute myocardial infarction under remote home monitoring. Inclusion criteria: Diagnosis in accordance with the "Guidelines for the Diagnosis and Treatment of Acute ST-segment Elevation Myocardial Infarction"; AMI patients after discharge; age 18-75; New York Heart Association (NYHA) cardiac function class I-III; the patient himself Or the primary caregiver will use a smartphone; the subject himself signs the informed consent.
Exclusion criteria
Exclusion criteria: 1) Effectiveness of rTMS precise regulation combined with upper limb rehabilitation robot intervention on upper limb dysfunction after cerebral infarction. Exclusion criteria: history of epilepsy, history of idiopathic epilepsy in first-degree relatives and use of epilepsy drugs; severe cognitive and communication impairments Cooperate with evaluation and treatment; posterior circulation cerebral infarction; wearing a pacemaker, intracranial metal implants; severe cervical spondylosis including severe cervical spinal canal stenosis, cervical instability; complete occlusion of the internal carotid artery; direct damage to the stimulated area, Skull defects; patients with claustrophobia and uncooperative fMRI examination; pregnant women, etc. 2) Effectiveness of cerebellar intermittent theta burst stimulation regulation combined with Tai Chi training in intervention on balance dysfunction after cerebral infarction. Exclusion criteria: history of epilepsy, history of idiopathic epilepsy in first-degree relatives and use of epileptogenic drugs; severe cognition and Communication disorders and unable to cooperate with evaluation and treatment; posterior circulation cerebral infarction; wearing a pacemaker, intracranial metal implants, or skull defects; balance dysfunction caused by other neurological diseases before the onset; claustrophobia and Patients who do not cooperate with fMRI examination; pregnant women, etc. 3) The effectiveness of multimodal neuromodulation combined with multi-channel functional electrical stimulation to assist walking intervention after spinal cord injury. Exclusion criteria: history of epilepsy, history of idiopathic epilepsy in first-degree relatives, and use of epilepsy drugs; severe Mental system diseases, severe cognitive and communication impairments that cannot cooperate with assessment and treatment; wear a cardiac pacemaker, have metal implants in the brain, or have skull defects; have metal implants in the lower limbs; the etiology and Related to other neurological diseases; severe spasticity, stiffness, contracture, osteoporosis and fractures of the lower limbs; progressive spinal cord injury, etc. 4) Effectiveness of high-power compound spectrum and peripheral functional magnetic stimulation combined with task-oriented training in intervention on peripheral paralysis caused by brachial plexus injury. Exclusion criteria: nerve root avulsion injury; nerve rupture without surgical anastomosis or cause of injury not resolved; damage to skin integrity, impact assessment; wearing a pacemaker, metal implants in the cervical spine; vascular injury, inflammation, tumor, Nerve damage caused by other reasons such as systemic diseases; severe cervical spondylosis, including severe cervical spinal stenosis, cervical spine instability; direct injury to the stimulated area; amputation; pregnant women, etc. 5) Effectiveness of aerobic exercise intervention for patients with acute myocardial infarction under remote home monitoring. Exclusion criteria: combined with other serious heart diseases (including: acute heart failure, cardiogenic shock, malignant arrhythmia, respiratory failure, severe heart valve disease, etc.); serious systemic organic disease (such as hematopoietic system, immune system, tumor, chronic kidney disease stage 4 and above, etc.); uncontrolled chronic disease, such as uncontrolled hypertension (resting blood pressure ? 160 /100mmHg); uncontrolled diabetes (random blood sugar>1
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subject 2:(1) Effectiveness of precise regulation of rTMS combined with upper limb rehabilitation robot in intervention on upper limb dysfunction after cerebral infarction.:FMA-UE;Subject 2:(2) The effectiveness of cerebellar intermittent theta burst stimulation combined with Tai Chi training in intervention on balance dysfunction after cerebral infarction:Berg Balance Scale.;Subject 2:(3) Effectiveness of multimodal neuromodulation combined with multichannel functional electrical stimulation to assist walking in intervention on walking dysfunction after spinal cord injury:LEMS lower extremity motor score;Subject 2:(4) Effectiveness of high-power compound spectrum and peripheral functional magnetic stimulation combined with task-oriented training in intervention on peripheral paralysis caused by brachial plexus injury:Brachial plexus injury function standard score of Chinese Medical Association Hand Surgery Society.;Subject 2:(5) Effectiveness of aerobic exercise intervention on exercise tolerance in patients with acute myocardial infarction under remote home monitoring:6 minutes walking distance.; | — |
Secondary
| Measure | Time frame |
|---|---|
| (1)Upper limb motor function: affected side arm movement survey test score;Ability of daily living activities;Limb spasticity assessment;MRI index: resting state MRI, brain structure image and diffusion tensor imaging;sEMG:RMS, iEMG, motion unit count and F wave amplitude distribution.;(2)Lower limb Fugl-Meyer score;Dynamic and static balance function detection: stability index, total length of center of gravity moving track, swing frequency, etc.3m stand up and walk test;Ability of daily living activities;MRI indicators: resting fMRI, brain structure image and DTI.;(3)Motor function: spinal cord injury walking Index II;Ability to perform activities of daily living, independence assessment of spinal cord injury;Limb spasticity assessment;Neuroelectrophysiological indicators: motor area mapping, MEPs amplitude, MEPs latency, central motor conduction time, SSR;MRI index.;(4)Pain: Digital scale (NRS);Neuroelectrophysiological indicators: motion conduction velocity and CMAP amplitude, skin sympathetic response (SSR) amplitude;Neuroultrasound: injured proximal/injured distal nerve cross-sectional area;MRI index: resting fMRI;Infrared thermogram;Hemodynamic monitoring.;(5)LVEF, left ventricular end-diastolic diameter;proBNP;ICF universal portfolio;SF-36 Quality of Life Scale;Seattle angina questionnaire (Seattleanginaquestionnaire, SAQ).Compliance (degree of completion); | — |
Countries
CHINA
Contacts
Public ContactHongxing WANG
Zhongda Hospital of Southeast University
Outcome results
None listed