Coronary microvascular disease
Conditions
Interventions
Gold Standard:1. Abnormality of stress (exercise or drug) myocardial perfusion imaging (perfusion reduction / defect) and partial or complete restoration of resting myocardial perfusion imaging
2. The coronary angiography-derived fractional flow reserve >0.8
3. Coronary angiography stenosis diameter < 50 %.
Index test:Index of diastolic microcirculatory resistance(IDMR)
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Over 18 years old and under 80 years old; 2. The patients with suspected myocardial ischemia; 3. The patients (or legal guardians) understand the research requirements and treatment procedures, and can provide written informed consent before specific examinations or procedures; 4. The patients are willing to comply with the clinical evaluation of the study protocol, including consent and can tolerance myocardial perfusion imaging (stressed by exercise or adenosine triphosphate), coronary angiography, and coronary angiography-derived fractional flow reserve measurement.
Exclusion criteria
Exclusion criteria: 1. The patients with myocardial infarction; 2. The patients have received organ transplantation or are waiting to receive organ transplantation; 3. The patients are receiving or planning to receive chemotherapy within 30 days before and after surgery; 4. The patients were allergic to iodine contrast agent and adenosine; 5. The complete blood count (CBC) of the patients was outside the reference range and confirmed clinically significant; 6. The patients with clear or suspected liver disease, including laboratory evidence of hepatitis; 7. The patients are undergoing dialysis or have a baseline serum creatinine level> 2.0 mg/dL (177 µmol/L); 8. The patients with bleeding tendency or history of coagulation disease or refusal of blood transfusion; 9. The patients are participating in clinical studies of other drugs or devices under study and have not reached their primary endpoint; 10. The patients are pregnant or lactating women (pregnancy tests are mandatory for women of childbearing age within 7 days before surgery).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Index of diastolic microcirculatory resistance(IDMR);sensitivity;specificity; | — |
Countries
China
Contacts
Public ContactHu Ai
Beijing Hospital
Outcome results
None listed