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Effect of remimazolam versus propofol for the induction of general anesthesia on cerebral blood flow and oxygen saturation in elderly patients undergoing carotid endarterectomy

Effect of remimazolam versus propofol for the induction of general anesthesia on cerebral blood flow and oxygen saturation in elderly patients undergoing carotid endarterectomy

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300070370
Enrollment
Unknown
Registered
2023-04-11
Start date
2021-07-01
Completion date
Unknown
Last updated
2023-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

carotid artery stenosis

Interventions

R group:Remimazolam induction
P group:Propofol induction

Sponsors

Suzhou Dushu Lake Hospital (Dushu Lake Hospital affiliated to Soochow University)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1)ASA classification I to III; (2) The degree of carotid artery stenosis was more than 70% confirmed by preoperative ultrasound diagnosis; (3) Sign informed consent on the basis of full understanding of the research; (4) CEA surgery is to be performed at an selected time.

Exclusion criteria

Exclusion criteria: (1) Have a clear history of allergy or prohibition to benzodiazepines, propofol, opiates, muscle relaxants and other drugs; (2) Complicated with serious cardiology diseases, such as acute myocardial infarction (including infarction within 6 months),acute heart failure, third degree atrioventricular block, unstable angina, severe valvular disease, etc. (3) Complicated with severe intracranial diseases, such as acute stroke, progressive stroke, etc.; (4) patients with serious endocrine diseases; (5) Liver and kidney dysfunction: (6) Patients with subclavian artery stenosis; (7) Patients suffering from severe mental illness or cognitive impairment, etc., are unable to smoothly cooperate with the study; (8) No informed consent has been obtained.

Design outcomes

Primary

MeasureTime frame
St02;Vm;

Secondary

MeasureTime frame
RI;Map;Hr;CI;

Countries

CHINA

Contacts

Public ContactJian Li

Suzhou Dushu Lake Hospital (Dushu Lake Hospital affiliated to Soochow University)

kentleesz@suda.edu.cn+86 13771704822

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 11, 2026