Multimodal magnetic resonance imaging-based study of electroconvulsive efficacy prediction in adolescents with depression: a multicenter prospective cohort study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300070354

Enrollment

Unknown

Registered

2023-04-10

Start date

2023-04-10

Completion date

Unknown

Last updated

2023-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major depressive disorder

Interventions

Modified electroconvulsive therapy group:N/A

Non-modified electroconvulsive therapy group:N/A

Healthy controls group:No intervention

Eligibility

Sex/Gender

All

Age

13 Years to 18 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for the modified electroconvulsive therapy (MECT) and non-modified electroconvulsive therapy (Non-MECT) groups: 1.Age 13-18 years. 2.Meeting a diagnosis of depression (MDD) from the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) based the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL). 3.A score of =40 on the Childhood Depression Rating Scale-Revised (CDRS-R). 4.Adequate audiovisual level to be able to complete this study. 5.Signed informed consent and signed by the subject and guardian. Healthy control group inclusion criteria. 1.Age 13-18 years. 2.Sufficient audio-visual level to be able to complete the study. 3.Signed informed consent form and signed by the subject and guardian.

Exclusion criteria

Exclusion criteria: Exclusion criteria for the modified electroconvulsive therapy (MECT) and non-modified electroconvulsive therapy (Non-MECT) groups: 1.The presence or previous presence of a serious medical, neurological or psychiatric condition (except in patients with MDD; anxiety co-morbidity is not considered an exclusion criterion, provided that MDD is the primary diagnosis and the main reason for seeking life-saving treatment) 2.Patients who have received electroconvulsive therapy within the last 12 months 3.Patients with a history of substance, drug abuse 4.Contraindications to anaesthesia or MRI 5.Lactating women or pregnant women. 6.Left-handedness. Exclusion criteria for healthy controls: 1.Presence or previous serious medical, neurological or psychiatric illness. 2.Patients with a history of substance or drug abuse. 3.Contraindications to MRI. 4.Lactating women or pregnant women. 5.Left-handedness.

Design outcomes

Primary

Measure	Time frame
CDRS-R;	—

Secondary

Measure	Time frame
SCARED;BDI;C-SSRS;CGI-I;CGI-S;RSS;functional magnetic resonance imaging of the brain;CTQ;OB/VQ;EHI;	—

Countries

China

Contacts

Public ContactXinyu Zhou

The First Affiliated Hospital of Chongqing Medical University

zhouxinyu@cqmu.edu.cn15823996993

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026