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The efficacy of esketamine for postoperative pain and depression in women undergoing second cesarean section

The efficacy of esketamine for postoperative pain and depression in women undergoing second cesarean section

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300070341
Enrollment
Unknown
Registered
2023-04-10
Start date
2023-04-13
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postpartum pain and depression

Interventions

ES+SF group :Esketamine + sufentanil
group B:Butorphanol + sufentanil
NS+SF group :normal saline + sufentanil

Sponsors

Lishui People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 45 years, American Society of Anesthesiologists (ASA) class II,BMI = 37 weeks); 5. Planned cesarean section under combined lumbar and rigid anesthesia with postoperative self-administered intravenous analgesia; 6. The patients or their family members were informed about the medications used in this study and voluntarily signed the informed consent forms to participate in this research.

Exclusion criteria

Exclusion criteria: 1.Complicated with hypertension, severe heart disease, impaired liver and kidney function, diabetes, eclampsia, preeclampsia, placental abruption, etc.; 2.Abnormal blood coagulation function and contraindications to spinal anesthesia; 3.Use of sedative or analgesic drugs within 2 hours before surgery; 4.Allergy to the study drug; 5.History of alcohol or drug dependence; 6.Complicated with mental system diseases and chronic pain diseases before surgery; 7.Complicated with COVID-19 infection. 8.Those with incomplete data or interrupted follow-up.

Design outcomes

Primary

MeasureTime frame
Uterine Contraction Pain Score(VAS-U);Incision Resting Pain Score(VAS-R);Incision Movement Pain Score(VAS-P);

Secondary

MeasureTime frame
Depression score;times of PCIA;The times of rescue analgesia;Maternal Satisfaction Score;First Push PCIA Time;The proportion of patients who receive analgesic drug rescue;

Countries

China

Contacts

Public ContactDai Hong

Lishui People's Hospital

946795481@qq.com+86 189 5709 1856

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026