The influence of the Minium Alveolar Concentration (MAC)-awake of Sevoflurane in Patients with frailty

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300070340

Enrollment

Unknown

Registered

2023-04-10

Start date

2023-04-10

Completion date

Unknown

Last updated

2023-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

older patients with preoperative frailty

Interventions

control group:to investigate the MAC-awake of sevoflurane in patients with normal patients

preoperative weakness group:to investigate the MAC-awake of sevoflurane in patients with frailty.

Eligibility

Sex/Gender

All

Age

65 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Patients who plan to undergo non-cardiac elective surgery under general anesthesia; 2. Over 65 years old; 3. ASA: Grade?-?; 4. Body weight is 40-80kg

Exclusion criteria

Exclusion criteria: 1. heart failure, severe arrhythmia, with serious liver and kidney diseases; 2. Preoperative neuropsychiatric diseases (including schizophrenia, depression, and mania); 3. Unable to complete the scale examination (due to dementia, deafness or language impairment); 4. Cerebrovascular accident (stroke, transient ischemic attack) within 3 months; 5. History of drug abuse and blood coagulation dysfunction; 6. No informed consent form was signed.

Design outcomes

Primary

Measure	Time frame
MAC-awake of sevoflurane;	—

Secondary

Measure	Time frame
MAP;HR;SpO2;	—

Countries

China

Contacts

Public ContactGao Zhixin

Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University

wy78963@163.com+86 138 5601 3602

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026