pulmonary arterial hypertension with respiratory faliure of newborn
Conditions
Interventions
iNO treatment group:nitric oxide inhalation
Sponsors
Beijing Children's Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The following conditions are met: 1. evidence of pulmonary arterial hypertension on cardiac ultrasound 2. who are receiving invasive respiratory support 3. oxygenation index (OI) >= 20 4. the age at initial treatment is >= 34 weeks,including corrected gestational age 5. The guardian fully understands the benefits and risks of this study, and is still willing to participate and sign the informed consent
Exclusion criteria
Exclusion criteria: Comply with any of the following: 1. OI >= 40 2. Use Extracorporeal Membrane Oxygen (ECMO) 3. Severe left heart dysplasia or duct-dependent congenital heart disease 4. methemoglobinemia defined as having more than 1% methemoglobin in the blood has been established 5. Congenital cardiac dysplasia 6. Degree II and above intracranial hemorrhage existed before NO inhalation 7. Subjects who are participating in clinical trials of other drugs or medical devices that the investigator deems inappropriate to participate in this clinical trial 5. Incomplete data
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OI at 1 h of iNO treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| OI at 24 h of iNO treatment;incidence of adverse events;OI at iNO is discontinued;Results in blood gas analysis;Settings of ventilation;Period of iNO application;Total hospital stay;Medical costs for hospitalization;Rate of discharge against medical advice; | — |
Countries
China
Contacts
Public ContactHei Mingyan
Beijing Children's Hospital Affiliated to Capital Medical University
Outcome results
None listed