septic shock in children
Conditions
Interventions
Gold Standard:Gold standard: the type of infectious pathogen is finally determined in the discharge diagnosis, and the judgment result is obtained after comprehensive analysis based on the detection r
Index test:Samples at the same time and at the same place shall be submitted for inspection by two detection methods to detect pathogens:
1. Traditional methods: microscopic examination of pathogen sm
Sponsors
Beijing Children’s Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
0.1 Years to 18 Years
Inclusion criteria
Inclusion criteria: During the study period, the children who met the diagnosis of septic shock were included in the PICU inpatients of Beijing Children's Hospital.The diagnostic criteria of children with septic shock are based on the diagnostic criteria in the Consensus of Experts on the Diagnosis and Treatment of Children's Septic Shock (2015): septic shock can be diagnosed as septic shock when the patients with sepsis have tissue perfusion insufficiency and cardiovascular dysfunction. It is manifested as (1) hypotension: blood pressure is lower than the 5th percentile of the age group, or systolic blood pressure is lower than 2 standard deviations of the normal value of the age group. (2) It is necessary to use vasoactive drugs to maintain blood pressure within the normal range [dopamine>5ug/kg. min or any dose of dobutamine, norepinephrine and epinephrine. (3) It has three of the following tissue hypoperfusion manifestations: changes in heart rate and pulse: peripheral arterial pulse is weak, and heart rate and pulse are faster. Skin changes: pale or gray, wet and cold, marbled. For example, warm shock can be manifested as warm limbs and dry skin. The capillary refilling time (CRT) is prolonged (>3s) (excluding the influence of ambient temperature), and the CRT can be normal during warm shock. Change of consciousness: early irritability or depression, and indifferent expression. In the late stage, consciousness is blurred, even coma and convulsion. After fluid resuscitation, the urine volume is still less than 0.5 ml/kg. h, lasting for at least 2 hours. Lactic acidosis (excluding other ischemic hypoxia and metabolic factors), arterial blood lactic acid>2mmol/L.
Exclusion criteria
Exclusion criteria: 1. Age: correction age = 18 years for adults; 2. No informed consent of family members; 3. The child died within 48 hours after admission; 4. Incomplete clinical data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensitivity;specificity;positive predictive value;negative predictive value;false negative rate;false positive rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| compliance rate;accuracy; | — |
Countries
China
Contacts
Public ContactLijuan Wang
Beijing Children’s Hospital, Capital Medical University
Outcome results
None listed