None listed
Conditions
Interventions
Propofol group :Sedation was delivered using target-controlled infusion (TCI). Propofol was delivered via the Marsh model, starting at an effect-site concentration of 1.0 µg/mL, with incremental of 0
Dexmedetomidine group:Sedation was delivered using target-controlled infusion (TCI). Dexmedetomidine was administered using the Dyck model, beginning at an effect-site concentration of 0.5 ng/mL, with
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: American Society of Anesthesiologists (ASA) class I-III patients aged 65 years or older under spinal anesthesia combined with sedation.
Exclusion criteria
Exclusion criteria: 1. BMI 30kg/m2; 2. History of drug abuse; 3. History of allergy to test drugs such as local anesthetic, propofol, dexmedetomidine, or egg allergy; 4. Preoperative bradycardia or conduction block; 5. Nervous system diseases; 6. Long-term use of psychoactive drugs; 7. Patients who could not cooperate to complete the assessment or questionnaire survey; 8. Refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electroencephalogram, EEG; | — |
Secondary
| Measure | Time frame |
|---|---|
| CAM delirium assessment;MoCA cognitive assessment; | — |
Countries
China
Contacts
Public ContactMin Li
Peking University Third Hospital
Outcome results
None listed