The effect and mechanism of modulation of contralateral premotor cortex on stroke patients with upper limb motor dysfunction based on Hebbain model

The effect and mechanism of transcranial magnetic stimulation of premotor cortex on upper limb motor function based on Hebbian mode

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300070311

Enrollment

Unknown

Registered

2023-04-10

Start date

2023-04-10

Completion date

Unknown

Last updated

2023-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

cM1 group:Conventional treatment of stroke + cM1 low-frequency rTMS

cPMd group:Conventional treatment of stroke +cPMd high-frequency rTMS

cPMd-iM1 PAS group:Conventional treatment of stroke +cPMd-iM1 PAS

PAS-train group:Conventional treatment of stroke+PAS and upper limb movement time locking intervention

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. patients diagnosed with cerebral infarction by MRI or CT (excluding small lacunar lesions) with upper limb motor dysfunction; 2. Age >= 18 years old and 3 months; 4. Unilateral hemisphere affected; 5. Brunnstrom stage ?-?; 6. Able to tolerate training and assessment for 1 hour with clear consciousness; 7. Those who volunteered to participate in this research project and signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with multiple strokes; 2. Bilateral hemispheric stroke; 3. History of Parkinson's disease, epilepsy or seizures; First-degree relatives with epilepsy history and use of epileptogenic drugs; 4. Contraindications to magnetic resonance and transcranial magnetic stimulation, such as metal implants in the body or head (except those in the Department of Stomatology); Implantation of pacemakers, defibrillators, cochlear implants, drug pumps, etc. 5. Recurrent headache of unknown cause unresponsive to medication; 6. Skull fracture and/or severe head injury; A history of head and/or brain surgery; 7. Serious heart, liver, kidney diseases or infectious diseases; 8. Severe cognitive, speech, psychological, spiritual, visual and hearing disorders; 9. Taking tricyclic antidepressants, psycholeptics, and other seizure threshold lowering medications; 10. Pregnant or lactating women; 11. Patients with limb motor function impairment before onset.

Design outcomes

Primary

Measure	Time frame
Fugl-Meyer assessment of upper extremity, FMA-UE;	—

Secondary

Measure	Time frame
Wolf motor function test, WMFT;Modified Bathel index, MBI;box and block test,BBT;fMRI;electrophysiological index;fNIRS;	—

Countries

China

Contacts

Public ContactChunlei Shan

Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine

shanclhappy@163.com+86 13816215058

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026