Oral Squamous carcinoma
Conditions
Interventions
Experimental group:Metformin after preoperative diagnosis of oral squamous carcinoma
control group:no intervention
Sponsors
Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with a clinical diagnosis of primary oral squamous cell carcinoma; 2. Patients for whom radical surgery is the preferred treatment option; 3. Aged 18-80 years; 4. Normal liver and kidney function; 5. Able to understand and complete a written informed consent form to sign; 6. Accept treatment and follow up.
Exclusion criteria
Exclusion criteria: 1. Patients with diabetes mellitus. (Patients with a history of gestational diabetes only will be allowed to be included in the study); 2. Patients with metformin allergy; 3. Patients with immune system disorders. (e.g. systemic lupus erythematosus, rheumatic heart disease, rheumatoid arthritis, scleroderma, primary platelet purple epilepsy, AIDS, etc.); 4. Patients with diseases that can cause tissue hypoxia (especially worsening of acute or chronic diseases), such as decompensated heart failure, respiratory failure, recent episodes of myocardial infarction, shock, etc.; 5. History of metformin administration in the last 6 months; 6. History of metabolic acidosis, including increased risk of ketoacidosis or lactic acidosis; 7. Pregnancy or lactation; 8. Patients with any other serious systemic disease; 9. Patients with a previous history of renal disease; 10. Patients with uncorrected vitamin B12 or folic acid deficiency; 11. Patients with other known active malignancies (excluding adequately treated basal cell/squamous cell skin cancer, carcinoma in situ or other cancers for which the patient has been disease-free for 2 years); 12. Patients receiving other experimental drug therapy. Unwilling to participate in this program without informed consent. Those who are unable to adhere to long-term medication and have difficulty following up with poor adherence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood Immune cell;organization Immune cell; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine;Liver and kidney function;lactic acid;Glycosylated hemoglobin; | — |
Countries
China
Contacts
Public ContactTong Su
Xiangya Hospital, Central South University
Outcome results
None listed