Neonatal bilirubin brain injury
Conditions
Interventions
observation group:decosahexaenoic acid
Sponsors
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1. Newborns aged over 35 weeks who met one of the following conditions were included in the high-risk group: (1) Serum total bilirubin (TSB) and percutaneous bilirubin (TcB) levels at the time of admission were in high-risk areas; (2) Jaundice occurs within 24 h after birth; (3) The mother and infant are incompatible with each other and have positive direct antihuman globulin tests, and there are other hemolytic diseases such as glucose-6-phosphate dehydrogenase deficiency (G6PD); (4) The siblings have received phototherapy; (5) Cranial hematoma or obvious bruise; (6) Poor nursing or excessive reduction of body weight when breastfeeding alone. 2. Premature infants aged from 30 weeks to 34 weeks+6 weeks who met one of the following conditions were included in the high-risk group: (1) Jaundice occurs within 24 h after birth; (2) The mother and infant are incompatible with each other and have a positive direct antihuman globulin test, and there are other hemolytic diseases such as glucose-6-phosphate dehydrogenase deficiency (G6PD); (3) The siblings have received phototherapy; (4) Cranial hematoma or obvious bruise; (5) Poor nursing or excessive reduction of body weight when breastfeeding alone.
Exclusion criteria
Exclusion criteria: 1. Children who were allergic to DHA-related components used in the research; 2. Severe infection combined with dysfunction of liver, kidney and other vital organs; 3. Children with metabolic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum neuron-specific enolase;transcutaneous measurement;nuclear magnetic resonance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Brainstem evoked potential; | — |
Countries
China
Contacts
Public ContactHao Wei
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Outcome results
None listed