Chronic postoperative pain
Conditions
Interventions
Experimental group :intraoperative S-ketamine 0.2 mg/kg/h+PCIA contains S-ketamine
Control group:Use the same type of syringe to pump saline during the operation, and do not use the analgesia pump containing Esketamine after the operation
Sponsors
People's Liberation Army Joint Logistic Support Force 920th Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients will be included if they are older than 18 years old but younger than 80 years old and ASA less than III receiving elective spine fusion surgery under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. The American Association of Anesthesiologists has a surgical risk rating of IV or V; 2. Preoperative liver and kidney injury (serum creatinine > 2.0mg/dL); 3. Unstable ischemic heart disease; 4. History of cerebral hemorrhage, elevated intracranial pressure, and intraocular pressure; 5. History of preoperative opioid abuse and alcohol abuse; 6. Previous or current mental illness and pregnant women; 7. Those who are contraindicated in the use of ketamine and anesthetic drugs; 8. Will not cause patient controlled intravenous analgesia or inability to communicate and cooperate due to language or intellectual disabilities; 9. Untreated or insufficiently treated patients with hyperthyroidism; 10. Aneurysmal vascular disease or venous malformation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the NRS of the surgical site at rest and activity ; | — |
Secondary
| Measure | Time frame |
|---|---|
| the NRS of the incision at rest and activity ;the ODI scale;the DN4 scale;the incidence of CPSP ; | — |
Countries
China
Contacts
Public ContactLi Na
People's Liberation Army Joint Logistic Support Force 920th Hospital
Outcome results
None listed