Chronic venous insufficiency of the lower extremities
Conditions
Interventions
Control Group:placebo
Sponsors
Shanghai Pudong Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 18 to 70 years old, no gender limitation; 2. Patients with CVI diagnosed by the researcher, and under conservative treatment with CEAP <= grade 3 or patients with pain,soreness or other clinical symptoms 1 month after operation; 3. Doppler ultrasound or CTV confirmed the presence of venous insufficiency of lower limbs; 4. Understand and agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients whose coagulation dysfunction will affect the outcome of this study according to the judgment of the investigator; 2. Patients with severe CVI, such as venous ulcer, CEAP >= grade 4 or patients with CEAP grade 4 or 5 without surgical indication; 3. Patients with acute inflammation; 4. CTV confirmed that patients with iliac vein compression, or PTS manifestated that patients need or can be performed surgical treatment or intracavitary recanalization; 5. Patients who are judged by the investigator to be unsuitable to participate in this clinical trial, such as cardiogenic edema, nephrogenic edema or hypoproteinemic edema; 6. Patients who received edema relief treatment within 2 weeks; 7. Patients with expected survival less than 1 year; 8. Known hypersensitivity or intolerance to the study drug components; 9. Participated in clinical trials of other drugs in the past three months or participated in other clinical trials during this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Circumference of ankle; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score for limb pain;venous clinical severity score, VCSS rating; | — |
Countries
China
Contacts
Public ContactYu Bo
Shanghai Pudong Hospital
Outcome results
None listed