The research on the relationship among perioperative neurocognitive function, multimodal brain MRI and inflammatory mediators after general anesthesia

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300070226

Enrollment

Unknown

Registered

2023-04-06

Start date

2023-04-15

Completion date

Unknown

Last updated

2023-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid and breast diseases

Interventions

Preoperative and postoperative cognitive function assessment:Total intravenous anesthesia

Preoperative and postoperative cognitive function assessment:Total inhalation anesthesia

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients aged 18-80 years undergoing breast or thyroid surgery under general anesthesia for 1-3 hours.

Exclusion criteria

Exclusion criteria: Patients with a preoperative Montreal Cognitive Assessment Scale (MoCA) score of less than 26, current or previous history of mental illness, use of sedatives or antidepressants, drug dependence, alcohol abuse, severe hearing or visual or motor impairment, and acute infectious disease

Design outcomes

Primary

Measure	Time frame
Multimodal magnetic resonance of the brain;	—

Secondary

Measure	Time frame
plasma tumor necrosis factor-a;plasma interleukin-6;plasma interleukin-8;plasma s100ß;plasma sCD14;plasma sTLR4;	—

Countries

China

Contacts

Public ContactMa Ling

Shengjing Hospital Affiliated to China Medical University

mal@cmu.edu.cn+86 189 4025 6927

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026