Lung protection during one-lung ventilation
Conditions
Interventions
Conventional group (group C):One-lung ventilation was performed before opening pleura. In group C, after the start of one-lung ventilation, 5 mL/kg (PBW), PEEP 5 cmH2O, respiratory rate (RR) 12~18/min
Driving Pressure Titration Group (Group P):in group P, that optimal tidal volume was titrate from 8 mL/kg (PBW) according to the drive pressure after OLV, and the RR was 12 bpm during the titration pe
Sponsors
Ningxia Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients undergoing elective pulmonary lobectomy, age 18 - 65 years, gender, body mass index (BMI) 18.5 - 23.9 kg/m2, ASA class II-III.
Exclusion criteria
Exclusion criteria: Patients with severe heart, brain, liver and kidney diseases, patients with previous lung surgery, patients with FEV1/FVC < 70%, patients diagnosed with restrictive lung disease, patients with preoperative imaging report of pleural effusion, atelectasis or lung infection, patients with preoperative hemoglobin < 9 g/dL, patients with preoperative SaO2 < 90%.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oxygenation index;Respiratory mechanics parameters (plateau, peak and drive pressures and dynamic compliance); | — |
Secondary
| Measure | Time frame |
|---|---|
| Partial pressure of arterial oxygen (PaO2);Arterial partial pressure of carbon dioxide (PaCO2);Intrapulmonary shunt rate (Qs/Qt);Respiratory Index (RI);Two-lung ventilation for 10 min (T0), one-lung ventilation for 15 min (T1), one-lung ventilation for 30 min (T2), one-lung ventilation for 60 min (T3), resumption of two-lung ventilation for 10 min (T4);Incidence of postoperative pulmonary complications;Dead space volume (VD/VT); | — |
Countries
China
Contacts
Public ContactHongxing Min
Ningxia Medical University General Hospital
Outcome results
None listed