Helicobacter pylori infection in chronic atrophic gastritis
Conditions
Interventions
test team:H. pylori eradication according to drug resistance cause detection
control group Empirical :Empirical eradication of Helicobacter pylori
Sponsors
Civil Aviation General Hospital, Chaoyang, Beijing
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Select 18-75 years old (including both ends), gender is not limited; 2) Meet the diagnostic conditions of chronic atrophic gastritis in China Consensus Opinions on Chronic Gastritis, and have positive Hp by 14C or 13C breath test; 3), the primary eradication of Helicobacter pylori; 4), with symptoms of indigestion (such as: upper abdominal pain, acid reflux, heartburn, upper abdominal distension, nausea); 5) Positive PCR test of Helicobacter pylori in the gastric mucosa; 6)
Exclusion criteria
Exclusion criteria: 1) Those who have used proton pump inhibitors or H2 receptor antagonists, antibiotics, bismuth agents, or gastric mucosal protectors within 4 weeks before screening; 2) Repeated use (use for 5 times or more within 1 year) or long-term use (continuous use for 10 weeks or more); 3) Those who are allergic to any component of the test-related drugs (bismuth agent, esiprazole, antibiotics [penicillin (amoxicillin, etc.), macrolides (clarithromycin, etc.), 4) Patients with malignant tumors or a history of esophageal and gastrointestinal surgery; 5) Patients with pyloric obstruction, gastric perforation, esophageal erosion and ulcer, esophagitis and Zhuo-Ai syndrome; 6) Patients with acute upper gastrointestinal bleeding within 1 week before screening 7) To take drugs or non-steroidal anti-inflammatory drugs that affect the anticoagulant system, coagulation system and fibrinolytic system during the test; 8) Combined with other serious cardiac, liver and renal insufficiency (ALT, AST> 1.5 times the upper limit of normal value or the upper limit of Cr> normal value), anemia (Hb <90g / L) and other serious hematopoietic and coagulation system diseases failed to be effectively controlled; 9) Pregnant or lactating women, or subjects with a positive pregnancy examination, or a birth plan within 6 months of the screening examination; 10) Have a history of drug or alcohol abuse within 1 year prior to screening, or do not agree to comply with the provisions of the trial (including alcohol prohibition) during the study; 11) The investigator is not suitable to participate in clinical trials
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The H. pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pathological changes in atrophic gastritis;Adverse reaction rate; | — |
Countries
China
Contacts
Public ContactJianping Cheng
Civil Aviation General Hospital, Chaoyang, Beijing
Outcome results
None listed