Depression
Conditions
Interventions
Experimental group:esketamine
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
14 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Clinically diagnosed by a psychiatrist as a depressive disorder without psychotic symptoms, and meet the diagnostic criteria for depression without psychotic symptoms in the American Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-5)) ; 2. Patients with imminent suicide risk: including suicidal ideation, suicide attempt and suicide attempt; 3. 14= age =70
Exclusion criteria
Exclusion criteria: 1. A history of substance dependence; 2. Psychotic symptoms within six months; 3. Patients who have been treated with racemic ketamine; 4. Patients who received MECT within 1 month; 5. Associated with organic brain diseases; 6. Depression is caused by other organic diseases or drugs; 7. Intellectual disability and other neurological diseases affecting cognitive function; 8. Patients who are contraindicated in the use of esketamine; 9. Patients who cannot cooperate; 10. Illiteracy, blindness, deafness, etc. that affect the evaluation of curative effect and cognitive function test; 11. Other situations that the researchers think should not be included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| COLUMBIA-SUICIDE SEVERITY RATING SCALE;Montgomery-Asberg Depression Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Clinician Administered Dissociative States Scale;Hamilton Anxiety Scale;Clinical Global Impression;Social Function Rating Scale; | — |
Countries
China
Contacts
Public ContactZheLi
West China Hospital of Sichuan University
Outcome results
None listed