manlignant hematlogy
Conditions
Interventions
MSC Group:Mesenchymal stem cell infusion
Sponsors
Children's Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
No minimum to 16 Years
Inclusion criteria
Inclusion criteria: 1) Children with sequential Hematopoietic stem cell transfusion are limited to haploidentical or umbilical cord blood transplants. 2) Children with Hematopoietic stem cell 3-4 degrees of aGVHD or chronic generalized GVHD who are glucocorticoid resistant or even ineffective. 3) Children with poor engraftment after Hematopoietic stem cell transplantation. 4) Children with more than 3 degrees of Bo after transplantation. 5) Children with full informed consent signed according to the patient's wishes.
Exclusion criteria
Exclusion criteria: 1) Relapse of the primary disease after Transplantation. 2) Positive for four infectious diseases (syphilis, HIV, Hepatitis B, Hepatitis C) or complicated with other severe infections before transplantation. 3) Significant lack of compliance to complete clinical trials (such as patients with uncontrolled mental disorders) , 4) Patients participating in other clinical trials at the same time. 5) Patients who were not considered suitable for enrollment by other researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bilirubin;Transaminase;Alkaline phosphatase;IL-2;CMV;EBV;Amount of diarrhoea; | — |
Countries
China
Contacts
Public ContactHu Shaoyan
Children's Hospital of Soochow University
Outcome results
None listed