Skip to content

Anxiety-depression-like behavior causes the hypothalamic-pituitary-ovarian axis Endocrine abnormalities lead to infertility

Anxiety-depression-like behavior causes the hypothalamic-pituitary-ovarian axis Endocrine abnormalities lead to infertility

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300070176
Enrollment
Unknown
Registered
2023-04-04
Start date
2023-04-05
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

anxiety

Interventions

Anxiety depression infertility group:Intestinal probiotics were given
Non-anxiety depression infertility group:no
Normal group:no

Sponsors

Affiliated Reproductive Hospital of Jiangxi University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 60 patients with normal sexual life, no contraception, no pregnancy for more than 1 year and no pregnancy, all meeting the clinical diagnosis criteria of infertility, all newly diagnosed patients aged 20-40 years old, body mass index ?28kg/m2.

Exclusion criteria

Exclusion criteria: Exclusion criteria: patients with hypertension, diabetes, obvious constipation, diarrhea; Patients who have taken antibiotics or probiotics orally within the last month. In addition, 30 people in the normal group had no hypertension, diabetes, constipation and diarrhea, no infertility history, and no oral antibiotics or probiotics in the past month. All the enrolled people had the education level of junior high school or above, and could understand and complete the relevant self-rating scale by themselves.

Design outcomes

Primary

MeasureTime frame
Changes of monoamine neurotransmitter concentration after intestinal probiotics intervention;Changes of HPO hormone levels after intestinal probiotics intervention;

Secondary

MeasureTime frame
Correlation between anxiety-depression-like behavior and monoamine neurotransmitter concentrations;Association of anxiety-depression-like behavior with HPO hormone levels and infertility;

Countries

China

Contacts

Public ContactChen Weijun

Affiliated Reproductive Hospital of Jiangxi University of Traditional Chinese Medicine

112307068@qq.com13807062856

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026