Parkinson's disease.
Conditions
Interventions
Parkinson's patients group:NO
GBA gene mutation group:NO
LAKK2 gene mutation group:NO
Non -motor disorder group:NO
Sponsors
The First Affiliated Hospital of University of South China
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: ?Parkinson's patients group: 100 cases of Parkinson's patients diagnosed in the neurology department of our hospital were collected. standard constrain: (1) The enrolled PD patients met the diagnostic criteria for primary PD in MDS in 2015 and the PD diagnostic criteria formulated by the Parkinson's Disease and Movement Disorders Group of the Neurology Branch of the Chinese Medical Association. H-Y stage includes =2.5. Stages were definitively diagnosed by at least two neurodegenerative disease specialists. the (2) Age = 50 years old (3) Not receiving relevant drug treatment (4) Sign the informed consent ?GBA gene mutation group: 100 cases of patients with GBA mutation confirmed by genetic testing in the neurology department of our hospital were collected, including 50 patients with PD-like symptoms and 50 asymptomatic patients. standard constrain: (1) Enrolled patients were enrolled based on the results of genetic testing reports or after screening and consent of the family members of patients diagnosed with PD GBA. Stages were definitively diagnosed by at least two neurodegenerative disease specialists. the (2) Age = 40 years old (3) Not receiving relevant drug treatment (4) Sign the informed consent ?LAKK2 gene mutation group: Collect 100 cases of LAKK2 mutation patients or immediate family members who were confirmed by genetic testing in the Department of Neurology of our hospital, including 50 patients with PD-like symptoms and 50 asymptomatic cases. standard constrain: (1) Enrolled patients were enrolled based on the results of genetic testing reports or after the screening and consent of the family members of patients diagnosed with LAKK2. Stages were definitively diagnosed by at least two neurodegenerative disease specialists. the (2) Age = 50 years old (3) Not receiving relevant drug treatment (4) Sign the informed consent ?Non-motor disorder group: two types of non-motor disorders were diagnosed in the Department of Neurology of our hospital: the first subgroup was 100 cases of olfactory disorder group, including 50 patients with olfactory disorder and PD-like symptoms, and 50 cases of olfactory disorder without PD symptoms The second subgroup was the RBD group of 100 cases, including 50 cases of RBD patients with similar PD symptoms and 50 cases of RBD patients without PD symptoms. standard constrain: (1) The enrolled PD patients met the diagnostic criteria for primary PD in MDS in 2015 and the PD diagnostic criteria formulated by the Parkinson's Disease and Movement Disorders Group of the Neurology Branch of the Chinese Medical Association. Diagnosed by at least two neurodegenerative disease experts, PD patients with olfactory disorder or RBD non-motor disorder. the (2) Age = 50 years old (3) Not receiving relevant drug treatment (4) Sign the informed consent ?Healthy control group: 100 healthy subjects were recruited. (1) Previous health (2) Age = 50 years old (3) Sign the informed consent
Exclusion criteria
Exclusion criteria: (1) Secondary Parkinson's syndrome and Parkinson's plus syndrome caused by other reasons such as brain infection, trauma, poisoning, drug-induced, etc.; (2) Combined with organic diseases such as acute and chronic cerebrovascular diseases, epilepsy, and intracranial space-occupying; (3) Combined with Alzheimer's disease, corticobasal degeneration, vascular dementia, etc. and other possible causes Diseases that impair cognitive function; (4) Patients with severe cardiac insufficiency or hepatic and renal insufficiency; (5) History of mental illness (depression, anxiety, etc.); (6) Aphasia, delirium, disturbance of consciousness and other diseases that affect the assessment of cognitive function; (7) Those receiving intracranial surgery for Parkinson's disease, those with MRI contraindications such as internal metal implants and claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Head 3.0T MRI;GBA genetic testing;LAKK2 genetic testing;Cognitive scale assessment; | — |
Countries
China
Contacts
Public ContactHong Zhou
The First Affiliated Hospital of University of South China
Outcome results
None listed