Severe liver failure
Conditions
Interventions
The 3h treatment group:3h therapeutic dose
The 4h treatment group:4h therapeutic dose
The 5h treatment group:5h therapeutic dose
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: ? The patients with liver failure admitted to West China Hospital of Sichuan University meet the indications of artificial liver therapy stipulated in Expert Consensus on Clinical Application of Artificial Liver Blood Purification Technology (2022 Edition), that is, "patients with pre-, early-stage, mid-stage and late-stage liver failure caused by various causes;Patients with end-stage liver disease waiting for liver source before liver transplantation, rejection after liver transplantation, and non-functional liver transplantation;Patients with severe cholestatic liver disease and severe hyperbilirubinemia caused by various causes;Other diseases, such as sepsis with severe liver injury or multiple organ dysfunction syndrome, acute poisoning, etc. "? Age 18-70 years old;? Total bilirubin >200umol/L;? Stable hemodynamics and tolerance to artificial liver therapy;? The patient agrees and signs the informed consent voluntarily.
Exclusion criteria
Exclusion criteria: ? Hemodynamic instability (blood pressure <90/60mmHg);? Mental illness or other reasons can not cooperate with treatment;? Patients with severe active bleeding or disseminated intravascular coagulation; ? Allergic to consumables, blood products or drugs used in the treatment;? The same patient was only included in one DPMAS treatment, and the researchers who had participated in this study were no longer included;? Other researchers think it is not suitable to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total bilirubin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory factor; | — |
Countries
China
Contacts
Public ContactYingying Yang
West China Hospital, Sichuan University
Outcome results
None listed