Immunocheckpoint inhibitor-associated pneumonia
Conditions
Interventions
Sober sedation group:Mode of anesthesia
Muscle relaxation group under general anesthesia:Mode of anesthesia
Sponsors
Xiamen University Zhongshan Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 120 Years
Inclusion criteria
Inclusion criteria: ? A history of taking immune checkpoint inhibitors ? New symptoms or aggravation of original symptoms, including dyspnea, cough, chest pain, fever, hypoxia, etc. ? New pulmonary lesions were found on imaging, such as ground glass shadow, patch shadow or solid shadow, grid shadow, fibrous cable shadow, nodular shadow, etc
Exclusion criteria
Exclusion criteria: ?Patients with contraindications of routine bronchoscopy ? Patients with uncorrectable coagulopathy, hemodynamic instability, and severe respiratory failure (arterial oxygen partial pressure still <60 mmHg after oxygen administration or mechanical ventilation) ? Uncontrolled pulmonary hypertension or hypertension ?Poor lung function: lung carbon monoxide dispersion capacity <35% or forced vital capacity <50% ?The localized lesions of the intended biopsy were close to the large vessels, cavities or bullae of the lung.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Operating time;Recovery time from anesthesia;Patient fit;Pathological diagnosis rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| The number and size of specimens; | — |
Countries
China
Contacts
Public ContactPing-Yang Hong
Xiamen University Zhongshan Hospital
Outcome results
None listed