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Integrating transcriptomics and metabolomics helps reveal mechanisms and potential therapeutic targets in critically ill patients with intensive care unit—acquired weakness (ICUAW) and muscle wasting

Integrating transcriptomics and metabolomics helps reveal mechanisms and potential therapeutic targets in critically ill patients with intensive care unit—acquired weakness (ICUAW) and muscle wasting

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300070108
Enrollment
Unknown
Registered
2023-04-03
Start date
2023-04-03
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis

Interventions

without muscle atrophy Group:N/A
ICUAW Group:N/A

Sponsors

Tangdu Hospital, PLA Air Force Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: ? Over the age of 18; ? It meets the definition of sepsis 3.0; ? The informed consent has been signed.

Exclusion criteria

Exclusion criteria: ? non-sepsis cases; ? Refractory shock (death within 24 hours) or the source of infection cannot be eliminated; ? Advanced tumor; ? Cases that refused active rescue; ? Long-term use of hormone or immunosuppressive therapy, including the application of anti-rejection drugs after organ transplantation; ? Severe craniocerebral trauma (based on craniocerebral CT); 8 points); ? Pregnant or lactating women; ? Patients receiving radiotherapy and chemotherapy within 30 days; ?HIV infection; ? Serious cardiovascular and cerebrovascular events and other factors that require long-term life support.

Design outcomes

Primary

MeasureTime frame
Charlson comorbidity index;FRAIL Infirmity Scale;IL-6;

Secondary

MeasureTime frame
high-sensitivity C-reactive protein;

Countries

China

Contacts

Public Contactpu Li

Tangdu Hospital, PLA Air Force Military Medical University

hero20221010@126.com15829261963

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026