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Effect of high dose remifentanil combined with propofol on nausea and vomiting after gynecological endoscopic surgery

Effect of high dose remifentanil combined with propofol on nausea and vomiting after gynecological endoscopic surgery

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300070104
Enrollment
Unknown
Registered
2023-04-03
Start date
2023-04-03
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nausea and vomiting

Interventions

High dose group:high dose remifentanil
Low dose group:Low dose remifentanil

Sponsors

The first affiliated hospital of Zhejiang university of traditional Chinese medicine.
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: With the consent of the hospital ethics Committee, informed consent and signature of the patients, 80 cases of patients undergoing elective gynecological endoscopic surgery were selected and randomly divided into high dose remifentanil group (group H) and low dose remifentanil group (group L), 40 cases in each group

Exclusion criteria

Exclusion criteria: Patients aged =60 years, malignant tumor patients, ASA>= grade ?, chronic pain and analgesic drug users, soybean oil or egg allergy, coronary heart disease,diabetes,smoker, Hb lower than 8g/L, asthma, hormone, opioid, antihistamine or antiemetics within 1 month before surgery, PONV history or sickness, body mass index greater than or equal to 28 or less than 18.

Design outcomes

Primary

MeasureTime frame
postoperative nause and vomiting;

Secondary

MeasureTime frame
Postoperative pain intensity using visual analog scale (VAS);the time to first postoperative analgesic requirement;cumulative volume of a patient- controlled analgesia (PCA) containing sulfentainil over 48 hr;intraoperative hemodynamicss;

Countries

china

Contacts

Public ContactGuoxiaowen

Zhejiang Provincial Hospital of Traditional Chinese Medicine.

Guoxiaowen1315@hotmail.com13757123712

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026