Central Retinal Artery and Vein Occlusion
Conditions
Interventions
Experimental group 1:Diagnostic ultrasound (High MI)
Experimental group 2:Diagnostic ultrasound Combined with Microbubble (High MI)
Experimental group 3:Diagnostic ultrasound Combined with Microbubble (Low MI)
Control group:No
Sponsors
Second Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Over 18 years old; 2, Consistent with the clinical manifestations of central retinal artery occlusion, such as sudden monocular painless rapid vision loss accompanied by ipsilateral relative afferent pupillary disorder (+). The typical manifestations of fundus examination are gray, edema, and relative red macula in the posterior pole retina (i.e. "cherry erythema"), and FFA may indicate slow segmental decreased blood flow in the retinal artery. 3, In line with the clinical manifestations of central retinal vein obstruction, such as sudden monocular painless vision loss, FFA suggests retinal vein obstruction, fundus examination of the typical manifestations of involved retinal vein tortuosity and dilation around the site of obstruction, internal retinal bleeding and macular edema; 4. Willing to participate in this study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Suffering from glaucoma or any other eye disease, neurological or systemic disease, etc., which may affect vision and visual field; 2. Exclude arteritis, such as erythrocyte sedimentation rate greater than 50mm/h, C-reactive protein greater than twice the normal value; Diseases related to abnormal immune function, such as lupus erythematosus, Sjogren's syndrome, etc. 3. Optic neuropathy after cataract surgery or caused by blood loss; 4. Recent (1 month) history of corneal surgery, retinal exfoliation, silicone oil filling or other intraocular surgery, and ocular erythema and pain; 5. Took other experimental drugs or participated in other clinical trials 3 months before study inclusion; 6. Patients who are allergic to contrast media and cannot undergo contrast-enhanced ultrasound; 7. For any reason, it is not suitable to cooperate with the study or the researcher thinks it is not suitable to be included in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vision;Visual field;Peak systolic velocity of the central retinal artery;End-diastolic velocity of the central retinal artery;Resistance index of the central retinal artery; | — |
Secondary
| Measure | Time frame |
|---|---|
| RNFL-TO;Thickness from the ILM line to the IPL line;Arm-to-retina time;Arterial phase;Peak systolic velocity of the central retinal vein;Peak systolic velocity of the posterior ciliary artery;End-diastolic velocity of the posterior ciliary artery;Resistance index of the posterior ciliary artery;Peak systolic velocity of the arteriae ophthalmosa;End-diastolic velocity of the arteriae ophthalmosa;Resistance index of the arteriae ophthalmosa;Super microvascular imaging observation;Time to peak;Maximum intensity;Rising time;Mean transit time;Area under the curve; | — |
Countries
China
Contacts
Public ContactPeijing Li
Second Affiliated Hospital of Army Medical University
Outcome results
None listed