breast cancer
Conditions
Interventions
Experimental group:Wen Tong acupoint+vitamin B1 tablets, mecobalamine tablets
Control group:vitamin B1 tablets, mecobalamine tablets
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Confirmed pathological diagnosis of breast cancer; (2) Patients with recurrence and metastasis who had received at least two or more chemotherapy regimens in the past; (3) The chemotherapy regimen is based on utidrone; (4) Aged between 18 and 75 years old; (5) Predicted survival =3 months; (5) ECOG score 0-2; (6) All patients have understanding and cognitive abilities and are able to independently answer the questionnaire,who agree to participate in the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with sensory motor disorders due to brain metastasis or other site metastasis, cerebral infarction and other cerebrovascular lesions. (2) Peripheral nervous system lesions caused by other systemic and metabolic diseases (such as severe diabetes). (3) Patients with autoimmune diseases such as myasthenia gravis. (4) Peripheral neurotoxicity induced by previous chemotherapy drugs (paclitaxel, platinum, vinblastine) has not recovered or this chemotherapy regimen contains oxaliplatin, cisplatin and vinblastine chemotherapy drugs. (5) There are skin lesions of hands and feet (such as eczema), or skin damage, infection at the selected acupoints, or a history of contact allergy of hands and feet. (6) Pregnant or lactating women. (7) Patients with contraindications to chemotherapy, such as heart, liver, kidney insufficiency, moderate or above anemia, coagulopathy, thrombocytopenia, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of CIPN;Time of CIPN;Severity of CIPN; | — |
Secondary
| Measure | Time frame |
|---|---|
| living quality;VAS pain grade;TCM syndrome score scale; | — |
Countries
China
Contacts
Public ContactWan Donggui
China-Japan Friendship Hospital
Outcome results
None listed