CT-guided puncture localization of pulmonary nodules
Conditions
Interventions
Group A1B1:Two placebos were taken orally before localization
Group A1B2:Pregabalin and placebo were taken orally before localization
Group A2B1:Paracetamol and tramadol and placebo were taken orally before localization
Group A2B2:Pregabalin and paracetamol and tramadol were taken orally before localization
Sponsors
Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ? Age of 18-65 years old; ? ASA?-?; ? Patients with pulmonary nodules who planned to undergo CT-guided puncture localization; ? Patients were informed and gave their signed consent to this study.
Exclusion criteria
Exclusion criteria: ? Patients with severe neurological or psychiatric diseases or epilepsy; ? Hypersensitivity to pregabalin and paracetamol and tramadol; ? Recent use of 5-hydroxytryptamine drugs (such as selective serotonin reuptake inhibitors and monoamine oxidase inhibitors); ? Recent regular use of other analgesics (such as opioids); ? Patients with a history of chronic chest pain before surgery; ? BMI=30kg/m2; ? Inability to communicate normally: hearing disorders, language comprehension disorders, mental diseases, etc. ? Patients with severe cardiovascular and cerebrovascular diseases and liver and kidney dysfunction before operation ? Suffering from severe respiratory diseases and obvious respiratory depression; ? Previous history of pulmonary surgery; 11 Patients who were deemed by the investigators to be ineligible to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic blood pressure after localization;Diastolic blood pressure after localization;Heart rate after Diastolic blood pressure after localization;Pulse oxygen saturation after localization;Incidence of moderate to severe pain;Proportion of rescue analgesia;Adverse reaction;The satisfaction of patients; | — |
Countries
China
Contacts
Public ContactZhao Linlin
Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed