Carotid atherosclerotic plaque
Conditions
Interventions
Intervention group:Tongxinluo Capsules
Placebo group:Placebo
Sponsors
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with carotid atherosclerotic plaque diagnosed by color Doppler ultrasound; 2. Patients aged from 40 to 75 years, regardless of gender; 3. Patients with lumen stenosis less than 70%; 4. Patients who can take medicine for a long time; 5. Patients with informed consent and those who signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with acute cardiovascular and cerebrovascular diseases; 2. Patients with previous history of cerebral hemorrhage; 3. Patients with a positive occult blood test;or patients with active ulcer and bleeding tendency, long-term use of anticoagulant drugs (such as warfarin); 4. Patients with severe arrhythmia, atrial fibrillation and heart failure; 5. Patients with severe primary diseases such as liver, kidney, hematopoietic system, endocrine system and respiratory system, whose liver function is more than 2 times higher than the upper limit of normal value, and Cr is higher than the normal value; 6. Pregnant or lactating women, women with pregnancy plans in the near future; 7. Patients with allergic constitution; 8. Patients who are taking lipid-lowering medications 9. Patients who are taking dual antiplatelet drugs; 10.Patients taking antibiotics for recent 2 weeks 11. Any other life-threatening or serious disease that cannot be treated for 12 months will affect the evaluation results; 12. Other diseases or mental disorders that researchers believe may limit efficacy evaluation or patient follow-up; 13. Pacemaker implantation, metallic foreign bodies in the body, claustrophobia and seizures are contraindicated by MRI; 14. Patients who have participated in clinical trials of other drugs in recent 4 weeks.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Stenosis rate;Intima media thickness;Normal Wall Index;thin fibrous cap;lipid-rich necrotic core volume;intraplaque hemorrhage volume;Plaque calcification volume;fibrous cap volume;blood lipids;blood pressure;hs-CRP;Vital signs;two liver functions;two renal function; | — |
Primary
| Measure | Time frame |
|---|---|
| Total plaque volume; | — |
Countries
China
Contacts
Public ContactShengxian Wu
Dongzhimen Hospital of Beijing University of traditional Chinese Medicine
Outcome results
None listed