idiopathic normal pressure
Conditions
Interventions
Gold Standard:There is currently no recognized gold standard for idiopathic normal pressure hydrocephalus. The current diagnosis of idiopathic normal-pressure hydrocephalus relies on the combined diag
Index test:Magnetic resonance imaging (MRI): Imaging indicators include DESH sign, EI index, Z-EI index, temporal angle, corpus callosum angle, high convexity and narrow midline subarachnoid space, en
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. The age of the patient is greater than or equal to 60 years old; 2. The clinical manifestations of the patient have any one or more symptoms of gait abnormality, cognitive dysfunction, and urinary incontinence; 3. The pressure of the cerebrospinal fluid puncture of the patient is in the normal range, and The routine biochemistry and culture of the cerebrospinal fluid showed no apparent abnormalities; 4. The patient's brain imaging showed enlarged ventricles (Evans index > 0.3 on CT or MRI images); 5. The patient completed the head CT and MRI coronal, horizontal and sagittal examine.
Exclusion criteria
Exclusion criteria: 1. The diagnosis of the patient is secondary hydrocephalus; 2. The patient has other diseases that lead to abnormal brain imaging, such as intracranial mass, cerebral hemorrhage, cerebral infarction, Alzheimer's disease, and other neurodegenerative diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| disproportionately enlarged subarachnoid space hydrocephalus;accuracy;Sensitivity;Specificity;Negative predictive value;positive predictive value;iNPHGS, idiopathic normal pressure hydrocephalus grade score ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Evans index;callosal angle;temporal horn;dilated Sylvian fissure;focal sulcal dilation;DWMH, deep white matter with high signal intensity;PVH, periventricular white matter high signal intensity Periventricular white matter high signal intensity;disproportionately enlarged subarachnoidspace hydrocephalus (DESH) scale;Simplified radscale; | — |
Countries
China
Contacts
Public ContactLiangxue Zhou
West China Hospital, Sichuan University
Outcome results
None listed