colorectal cancer
Conditions
Interventions
E-S group:1.5 mg/kg es-ketamine plus 3 µg/kg for postoperative venous self-controlled analgesia
S group:3 µg/kg for postoperative venous self-controlled analgesia
Sponsors
Dazhou Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients planned to undergo elective colorectal resection under general anesthesia; 2) Age= 60 years old
Exclusion criteria
Exclusion criteria: a) refuse to participate in the study; b) ASA grade IV and above; c) poorly controlled or untreated hypertensive patients (systolic/diastolic blood pressure at rest > 180/100 mmHg); d) unstable angina or myocardial infarction within the last 6 months; e) severe liver and kidney dysfunction; f) severe cognitive impairment, inability to complete delirium evaluation, neurological lesions, inability to cooperate with delirium evaluation; g) Those who are allergic to the drug ingredients of es-ketamine, sufentanil and ondansetron; h) Those who are receiving opioids for pain; i) alcohol or opioid addiction; j) refusal of the use of venous controlled analgesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of postoperative ileus: time from the end of surgery to the first postoperative bowel movement; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative 24h, 48h, 72h VAS scores;Opioid dosage within 72 hours after surgery;Incidence of awakening and postoperative delirium; | — |
Countries
China
Contacts
Public ContactYou Hongjiang
Dazhou Central Hospital
Outcome results
None listed