Effect of sevoflurane and total intravenous propofol on renal function in elderly patients after hip surgery: a randomized, controlled trial

Effect of sevoflurane and total intravenous propofol on renal function in elderly patients after hip surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300070049

Enrollment

Unknown

Registered

2023-03-31

Start date

2023-04-01

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hip fracture

Interventions

Propofol group:Maintenance of anesthesia with intravenous propofol

Sevoflurane group:Maintenance of anesthesia with inhaled sevoflurane

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged >= 60 years; 2. ASA class I-III; 3. Patients scheduled for elective hip surgery under general anesthesia with tracheal intubation.

Exclusion criteria

Exclusion criteria: 1. Trauma and emergency patients; 2. New York Heart Association (NYHA) class 3-4; 3. Body mass index (BMI) > 37 kg/m2; 4. Diabetes mellitus on insulin therapy; 5. Renal system disease, hepatic system disease, family history of malignant hyperthermia.

Design outcomes

Primary

Measure	Time frame
Estimated glomerular filtration rate (eGFR) 1 hour after surgery;	—

Secondary

Measure	Time frame
Acute kidney injury;Plasma renin concentration;Plasma arginine-vasopressin concentration;Serum creatinine;Serum cystatin C;Estimated glomerular filtration rate (eGFR) 24 hour after surgery;Urinary sodium concentration;Urine volume;Neutrophil gelatinase-associated lipid transport protein;	—

Countries

China

Contacts

Public ContactFuhai Ji

The First Affiliated Hospital of Soochow University

jifuhai@hotmail.com+86 13656207331

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026