Early esophageal neoplasms and precancerous lesions
Conditions
Interventions
control group:normal saline
experimental group:N-acetylcysteine solution
experimental group:Vitamin C solution
Sponsors
Shihezi University First Affiliated Hospital
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Those over 40 years of age who meet any of the following criteria: long-term resident in an area with a high incidence of esophageal cancer; A family history of esophageal tumors; Having high risk factors for esophageal cancer (smoking, heavy alcohol consumption, squamous cell carcinoma of the head, neck or respiratory tract, preference for high temperature and preserved food, poor oral hygiene, etc.); 2. Endoscopic screening for suspected esophageal lesions; 3. Patients requiring monitoring after endoscopic resection or radiotherapy for esophageal squamous cell carcinoma.
Exclusion criteria
Exclusion criteria: 1. Allergic to iodine, n-acetylcysteine, vitamin C or hyperthyroidism; 2. Advanced esophageal cancer, esophageal varices, esophageal ulcers, or other conditions that are not suitable for Lugol iodine endoscopy; 3. Severe GERD or reflux symptoms may affect the outcome indicators of the current study; 4. Postoperative esophageal stenosis affected endoscopic observation; 5. Can not cooperate with observation, including mental disorders, serious cardiopulmonary diseases, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual analogue scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate changes at time points before and after staining endoscopy;Endoscopic resolution improvement; | — |
Countries
China
Contacts
Public ContactTian Shuxin; Li Chenlu
Shihezi University First Affiliated Hospital
Outcome results
None listed