Open angle glaucoma
Conditions
Interventions
Treatment group:acupuncture + Routine intraocular pressure lowering therapy
Control group:Routine intraocular pressure lowering therapy
Sponsors
Shuguang hospital affiliated to Shang TCM university
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Sign the informed consent voluntarily as the subject. (2) Patients =18 years old, =70 years old, regardless of gender. (3) Patients with clinically confirmed POAG are currently receiving routine eye drops to reduce intraocular pressure. (4) Willing to comply with clinical research protocols. (5) No other eye diseases that may cause visual field damage or seriously affect the accuracy of visual field detection. (6) Patients with monocular disease were included in the diseased eye, and patients with binocular disease were included in the eye with mild lesions considering the accuracy of detection. (7) Daily life visual acuity =0.1 in the selected eye.
Exclusion criteria
Exclusion criteria: (1) Patients with acute angle-closure glaucoma, congenital glaucoma, secondary glaucoma and other types of glaucoma were included. (2) Patients with corneal disease, severe cataract or vitreous opacities that affect fundus examination and data collection. (3) Other medical conditions affecting RNFL, including a history of eye surgery, ametropia (myopia =-6.00D or hyperopia > +3.00) D diopter or > +1.00 astigatism), eye or orbital trauma, optic nerve atrophy, uveitis, diabetic retinopathy, any form of macular edema, age-related macular degeneration. (4) Severe cardiovascular diseases, such as coronary heart disease, ventricular hypertrophy, heart failure, etc. Patients with diabetes and other severe lung and kidney diseases (5) Diseases that may significantly affect voxelbased morphometry (VBM) and diffusion tensor imaging (DTI) parameters; These include patients with demyelinating diseases, autoimmune diseases, cardiovascular diseases, hypertension (blood pressure =140/90 mm Hg or on antihypertensive drugs), diabetes (fasting blood glucose =7.1 mmol/L, or on hypoglycemic drugs). (6) Pregnant and lactating women. (7) Patients with major depression, mania, schizophrenia and other mental diseases; Patients with Parkinson's disease, Alzheimer's disease, multiple sclerosis and other neurodegenerative changes were excluded. (8) Those who are using or need to take other drugs that affect the evaluation of efficacy. (9) Patients who could not guarantee the completion of treatment and follow-up requirements as prescribed during the trial. (10) Exclude addicts who are addicted to drugs, tobacco and alcohol. (11) Exclude the contraindications of fMRI, such as claustrophobia and internal ferromagnetic implantation, which cannot cooperate with the examination. (12) All patients were right-handed, and left-handed patients were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| scale and questionnaire;fMRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| perimetry;electrophysiology;intraocular tension; | — |
Countries
China
Contacts
Public ContactYu Ying
Shuguang hospital affiliated to Shang TCM university
Outcome results
None listed