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Safety, efficacy and the optimal duration of preoperative imatinib in locally advanced gastric gastrointestinal stromal tumors: A retrospective cohort study

Retrospective analysis of the safety, efficacy and optimal preoperative duration of imatinib in locally advanced gastrointestinal stromal tumors in a single center

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300070011
Enrollment
Unknown
Registered
2023-03-31
Start date
2023-04-01
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastrointestinal stromal tumor

Interventions

Preoperative imatinib treatment :None

Sponsors

Department of General Surgery, Zhongshan Hospital, Fudan University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria were (1) patients who were pathologically diagnosed with GIST by needle biopsy; (2) patients who were difficult to achieve R0 resection; (3) patients with massive tumors >10cm or tumors that required multi-visceral and extensive resection in whom intraoperative bleeding, rupture or iatrogenic dispersion were likely to occur; (4) patients whose tumors were located in special anatomical sites such as the gastroesophageal junction so that the function of the organ was easily damaged by surgery; and (5) patients at risk of postoperative recurrence, complications or mortality.

Exclusion criteria

Exclusion criteria: The exclusion criteria were (1) patients with recurrent and metastatic diseases; (2) patients with missing information; (3) non-surgical patients; and (4) patients with co-existing malignancies.

Design outcomes

Primary

MeasureTime frame
Relapse-free survival;

Secondary

MeasureTime frame
Date of last follow-up;Date of recurrence;Date of tumor metastasis;Gene mutation information;Mode of operation;Scope of operation;Tumor size;Mitotic counts;Age;Gender;

Countries

China

Contacts

Public ContactHou Yingyong

Department of General Surgery, Zhongshan Hospital, Fudan University School of Medicine

HouYingyong@zs-hospital.sh.cn021-64041990

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026