chronic obstructive pulmonary disease
Conditions
Interventions
Sponsors
The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine;Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Male
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: COPD patients: 1. Patients diagnosed with COPD, stable condition in the past 4 weeks without acute exacerbation; 2. 40=age=80 years old, both male and female; 3. Patients with FEV1 between 25% and 80% after inhalation of bronchodilators; 4. The patient had at least one moderate or severe acute exacerbation in the past year; 5. According to the GOLD recommended drug regimen, received stable western medicine treatment within 3 months before treatment; 6. The patient is willing to cooperate with the research and sign the informed consent. Healthy subjects: (1) 40 = age = 80 years old, both male and female; (2) Exclude the sub-health state according to the "Clinical Guidelines for Sub-health Traditional Chinese Medicine" issued by the Chinese Association of Traditional Chinese Medicine; (3) The subjects are willing to cooperate with the research and sign the informed consent. Note: Patients who meet the above two items at the same time can be included in this study.
Exclusion criteria
Exclusion criteria: COPD patients: (1) Combined with serious cardiovascular and cerebrovascular diseases (severe arrhythmia, myocardial infarction, heart failure, severe hypertension, cerebral hemorrhage and cerebral infarction), nervous system (tremor, peripheral neuropathy), blood system (severe anemia, etc.), immune system Systemic (immune diseases combined with lung damage), malignant tumors, etc.; (2) Subjects with active pulmonary tuberculosis, bronchial asthma, severe bronchiectasis, primary pulmonary hypertension, pulmonary interstitial disease or other active lung diseases; (3) After segmentectomy, wedge resection, lobectomy, pneumonectomy, or lung volume reduction surgery (including bronchoscopic lung volume reduction surgery) for COPD. (4) Continuous oxygen therapy is required according to the LTOT standard (oxygen therapy time>15h/d); (5) Those who cannot cooperate to complete the lung function test, cannot walk independently, and cannot cooperate to complete the questionnaire; (6) Sustained damage to the skin tissue at the acupuncture site, infection and coagulation dysfunction, and patients with skin allergies. (7) Patients who participated in other clinical trials or underwent acupuncture for respiratory diseases in the past 3 months; (8) Antibiotics have been used in the past 3 months; (9) Systemic glucocorticoids have been used in the past 1 month; (10) Subjects who have used probiotics and prebiotics for a long time; (11) Those with severe gastrointestinal diseases; (12) Pregnant and lactating women. Note: Patients who meet any of the above items will be excluded. Healthy subjects: (1) Diagnosis of other major diseases (such as hypertension, diabetes, heart disease, gastrointestinal diseases, tumors, etc.); (2) There is no abnormality in lung function test; (3) Antibiotics have been used in the past 3 months; (4) Systemic glucocorticoids have been used in the past 1 month; (5) Use of probiotics and prebiotics within the past 3 months; (6) Mental patients, patients with anxiety, depression, cognitive impairment, allergies; (7) Pregnant and lactating women. Note: Patients who meet any of the above items will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The COPD Assessment Test (CAT); | — |
Secondary
| Measure | Time frame |
|---|---|
| St George's respiratory questionnaire;Modified Medical Research Council;6 minutes walking distance;Adverse reaction rate;intestinal microbiota;inflammation;immunity; | — |
Countries
China
Contacts
Public Contactliang fanrong
Chengdu University of Traditional Chinese Medicine
Outcome results
None listed