refractory depression
Conditions
Interventions
NAc/ALIC-DBS group:Accept bilateral NAc/ALIC-DBS
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Age: 16-65 years old, males or females; 2) All the cases meet the diagnostic criteria of depressive disorder in the diagnostic and Statistical Manual of mental disorders - Fifth Edition (DSM-V); 3) HAMD-24 score >= 17 points; 4) The duration of depression was more than 2 years; or recurrent episodes, with at least 4 episodes (the duration of the current episode is at least 1 year); 5) Two or more antidepressants with different mechanisms were used with adequate dosage and duration (>= 8 weeks), and at least 3 failures with the treatment plan. The patient refused, could not tolerate or did not respond to the treatment of electroconvulsive therapy; 6) During the whole trial, female with fertility must use medically acceptable contraceptive methods; 7) Every patient must be able to communicate fully, both the patient and legal guardian need to sign a written informed consent; 8) All the patients must have received psychological treatment for more than 6 weeks continuously without obvious improvement;
Exclusion criteria
Exclusion criteria: 1) Bipolar disorder, schizophrenic affective disorder, schizophrenia or other psychiatric disorders; 2) Severe personality disorder; 3) Severe physical disease or brain organic disease; 4) Alcohol or drug abuse and dependence were diagnosed according to DSM-IV diagnostic criteria within 1 year before therapy; 5) Patients with surgical contraindications, such as major medical comorbidities or anticoagulants cannot be stopped; 6) Preoperative brain magnetic resonance imaging (MRI) showed obvious structural imaging abnormalities; 7) Contraindication of MRI (excluding DBS electrodes or stimulator to be implanted); 8) Pregnancy or lactation; 9) The patient is participating in another study unrelated to the current study; 10) Any situation (family support; medical, psychological, social or geographical factors) that may endanger the patient's safety or prevent the patient from participating in the study at present or in the future;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Dpression Scale, HAMD-17; | — |
Secondary
| Measure | Time frame |
|---|---|
| WHOQOL-BREF;Montreal Cognitive Assessment, MoCA;Columbia suicide severity rating scale,CSSRS; | — |
Countries
China
Contacts
Public ContactWang Wei
West China Hospital, Sichuan University
Outcome results
None listed