post Ischemic stroke?cognitive?impairment
Conditions
Interventions
PSCI group:No
N-PSCI group:No
Healthy control group:No
Sponsors
Wusong Central Hospital, Baoshan District, Shanghai
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: There are three groups: 1. PSCI inclusion criteria: 1) Patients with acute ischemic stroke for the first time, the diagnostic criteria refer to the 2020 Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke; 2) Age 40-70 years old; 3) Onset time within 48 hours; 4) Patients with mild to moderate stroke had NIHSS score less than 6; 5) No cognitive impairment before the stroke event; 6) Cognitive impairment occurs within 6 months after the stroke event. The diagnostic criteria for cognitive impairment refer to the Expert Recommendations on the Diagnosis and Treatment Process of Cognitive Impairment in the Elderly in China in 2014. The details are as follows: 1) Cognitive impairment occurs in subjective and objective examinations; 2) Cognitive decline in one or more areas (complex attention, executive function, learning and memory, language, perception-activity, social cognition); 3) Exclude other systemic diseases that can cause brain function decline; 4) MoCA score was less than 26 points or activity of daily living (ADL) score was more than 16 points. 2. Inclusion criteria of N-PSCI: 1) Patients with acute ischemic stroke for the first time, the diagnostic criteria refer to the 2020 Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke; 2) Age 40-70 years old; 3) Onset time within 48 hours; 4) Patients with mild to moderate stroke had NIHSS score less than 6; 5) No cognitive impairment before the stroke event; 6) No cognitive impairment occurred after the stroke event. 3. Inclusion criteria of healthy control group:1) healthy elderly people matching gender, age and education level were selected in the community; age 40-70 years old; 2) without memory loss, mental impairment, no history of serious heart, brain, kidney disease, no history of alcohol and drug abuse; 3) no brain infarction or other vascular injury observed on T2 weighted image; 4) right-handed.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for PSCI group: 1) stroke caused by trauma or invasive surgery; 2) brain tumors; 3) Parkinson's disease; 4) Severe aphasia or other unstable medical conditions can affect brain function or affect the evaluation of cognitive function; 5) Currently diagnosed with active epilepsy; 6) Those who have severe sensory and perceptual impairment, so that they cannot complete the cognitive function measurement; 7) A history of mental illness such as depression, mania, delirium and anxiety. 2. Exclusion criteria for the N-PSCI group: 1) stroke caused by trauma or invasive surgery; 2) brain tumors; 3) Parkinson's disease; 4) Severe aphasia or other unstable medical conditions can affect brain function or affect the evaluation of cognitive function; 5) Currently diagnosed with active epilepsy; 6) Those who have severe sensory and perceptual impairment, so that they cannot complete the cognitive function measurement; 7) A history of mental illness such as depression, mania, delirium and anxiety.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| radial diffusivity;axial diffusivity; | — |
Primary
| Measure | Time frame |
|---|---|
| Fractional anisotropy;mean diffusion;ReHo diagram; | — |
Countries
China
Contacts
Public ContactJi Li
Outcome results
None listed