Gut microbiota, blood-brain barrier and cognitive function in elderly patients with coronary heart disease: a cross-sectional observational study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300069963

Enrollment

Unknown

Registered

2023-03-30

Start date

2023-03-30

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary artery disease

Interventions

NC Group:none

MCI Group:none

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Age 60-80 years old; (2) duration of education >=6 years; (3) Patients with coronary heart disease who are scheduled to receive coronary artery bypass surgery; (4) Agree and sign informed consent.

Exclusion criteria

Exclusion criteria: (1) a pre-existing psychological and/or psychiatric illness; (2) Have a clear history of stroke; (3) A history of Parkinson's disease and epilepsy; (4) Brain tumor or previous history of craniocerebral surgery; (5) severe hepatic or renal insufficiency; (6) Hearing impairment, vision impairment or speech impairment, which prevents communication; (7) Patients with oral antibiotics recently (3 consecutive days in the past month); (8) Not suitable for MRI examination.

Design outcomes

Primary

Measure	Time frame
Intestinal flora spectrum;Ktrans values;Neurofilament light;Cognitive function test score;MRI imaging parameters;P-tau protein level;	—

Countries

China

Contacts

Public ContactLichao Di

The Second Hospital of Hebei Medical University

dilichao@163.com+86 311 6600 3887

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026