Efficacy of a modified cocktail for adductor canal block combined with local infiltration analgesia in total knee arthroplasty: a prospective, double-blinded, randomized controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300069955

Enrollment

Unknown

Registered

2023-03-30

Start date

2023-03-30

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoarthritis of the knee

Interventions

Experimental group:adductor canal block combined with local infiltration analgesia

Control group:local infiltration analgesia

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Patients requiring unilateral initial TKA surgery due to knee osteoarthritis, joint destruction, and aseptic necrosis of the joint; (2) Age greater than 18 years old, regardless of gender; (3) The preoperative American Society of Anesthesiologists (ASA) anesthesia risk assessment was graded as Grade I-III; (4) Patients who have signed an informed consent form.

Exclusion criteria

Exclusion criteria: (1) Long-term use of opioids (daily or almost daily use of opioids>3 months); (2) Alcohol or drug abuse or allergy to any drugs (local anesthetics, etc.) used in this study; (3) Psychopaths, language disorders, and inability to complete the visual analog scale (VAS); (4) Patients with neuropathy of the extremities on the surgical side have moderate or more joint deformities or stiffness on the surgical side; (5) Previous history of knee trauma, or bilateral knee sensory asymmetry; (6) Local skin infection and bleeding at the anesthesia puncture site; (7) Abnormal coagulation function (PT, APTT exceeding normal values, INR<=1.4), platelet count<80 × 109/L), patients with possible abnormal platelet function; (8) The surgeon or anesthesiologist believes that the patient is not suitable for inclusion.

Design outcomes

Primary

Measure	Time frame
Dosage of morphine within 24 h after surgery;	—

Secondary

Measure	Time frame
Total morphine consumption during hospitalization;Intraoperative consumption of opioids;Postoperative Visual Analogue Scale Score at rest;Postoperative Visual Analogue Scale Score at motion;Times of sleep interruption due to pain on the night of surgery;Postoperative quadriceps strength;Time until the first walkout of bed after surgery;Time to hospital discharge;postoperative adverse events;	—

Countries

China

Contacts

Public ContactYang Jing

West China Hospital, Sichuan University

yangjing@wchscu.cn+86 189 8060 2269

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026