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Prediction and mechanisms of increased risk of simple obesity complicated by type 2 diabetes in dampness status based on CD4+ T cell subpopulation imbalance: a multicenter, prospective, cohort study

Prediction and mechanisms of increased risk of simple obesity complicated by type 2 diabetes in dampness status based on CD4+ T cell subpopulation imbalance: a multicenter, prospective, cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300069939
Enrollment
Unknown
Registered
2023-03-29
Start date
2023-04-01
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Interventions

Non-Dampness Group:None
Dampness Group :None

Sponsors

Guangdong Provincial Hospital of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: (1) Age 18 to 60 years old. (2) Meet the Western medical diagnostic criteria for simple obesity stage 1. Referring to the Expert Consensus and Group Standards on Weight Management for Overweight or Obese People and Expert Consensus on Weight Management Process for Overweight or Obese People (2021) developed by the Chinese Medical Association and the Chinese Nutrition Society, BMI = 28kg/m2 or waist circumference = 90cm in men and = 85cm in women were used as diagnostic criteria for obesity, and secondary obesity was excluded to diagnose simple obesity. Obesity, without or with one or more kinds of overweight or obesity-related diseases in the early stage, without overweight or obesity-related diseases and their serious complications, are the diagnostic criteria of obesity 1. Note:?Overweight or obesity-related diseases in the early stage: maximum normal blood pressure, borderline elevated blood lipids, pre-diabetes, hyperuricemia, etc. ?Overweight or obesity-related diseases: T2DM, dyslipidemia, hypertension, coronary atherosclerotic heart disease, non-alcoholic fatty liver disease, polycystic ovary syndrome, female infertility, sleep apnea syndrome, osteoarthritis, gout, etc. (3) Severe complications of overweight or obesity-related diseases: myocardial infarction, heart failure, stroke, chronic complications of diabetes (retinopathy, renal insufficiency: glomerular filtration rate <60 ml/1.73 m2), cirrhosis of the liver, obesity-related cancer, etc. (3) Sign the informed consent form.

Exclusion criteria

Exclusion criteria: (1) Those with other conditions that clearly affect the study, such as diabetes-related genetic defects, autoimmune diseases, etc. (2) Those with a significant family history of diabetes mellitus. (3) Those who have used study-impacting interventions in the last 1 month, such as lipid-modifying drugs, weight loss drugs, glucocorticoids, cytotoxic agents or non-selective immunosuppressants (4) Those who have recovered from a major illness such as serious heart, liver, kidney, brain or serious infection within the last 1 month. (5) Those who have participated in other clinical trials within 3 months. (6) Pregnant or lactating women. (7) Unwilling collaborators and psychiatric patients.

Design outcomes

Primary

MeasureTime frame
Random blood glucose;Fasting blood glucose;Plasma glucose at 2 hours after an oral glucose load;CD4+ T cell subpopulation;

Countries

China

Contacts

Public ContactFan Guanjie

Guangdong Provincial Hospital of Chinese Medicine

13925119990@139.com+86 13925119990

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026