day surgery
Conditions
Interventions
Remimazolam group:Anesthesia induction: remiazolam 0.3 mg/kg, and anesthesia maintenance: remimazolam 1 mg/kg/h
BIS40-60 during the anesthesia period
Propofol group:Anesthesia induction: propofol 2 mg/kg, and anesthesia maintenance: propofol 4-8 mg/kg/h
Sponsors
The first People's Hospital of Lianyungang
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1)18<= age < 65 years, gender is not limited; 2) undergoing day surgery and Anesthesia time =2h; 3) ASA I-II; 4)18kg/m2 < BMI < 30kg/m2; 5) Primary school diploma or above, able to complete the scale measurement; 6) To have a clear understanding of the study, to participate voluntarily in the study and to have their informed consent signed by them.
Exclusion criteria
Exclusion criteria: 1) Patients with moderate to severe head trauma or intracranial hypertension in the past three months; 2) Asthma, glaucoma, cardiac cerebrovascular disease, and severe liver and kidney dysfunction; 3) Preoperative diagnosis of mental neurological disorder or long-term use of psychotropic drugs, benzodiazepine, alcohol or sedatives; 4) Patients with a history of epilepsy or a family history of epilepsy; 5) A woman during pregnancy or lactation; 6) Allergic or contraindicated to any drug in the test; 7) Those who could not cooperate with MMSE and whose score was lower than the lowest score of corresponding educational level (illiterate <=17 points, primary school <=20 points, middle school <=22 points, university <=23 points) ; 8) Other conditions in which the researchers considered it inappropriate to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall recovery as assessed by PQRS on the first postoperative day; | — |
Secondary
| Measure | Time frame |
|---|---|
| The recovery in all areas of PQRS at 15 min, 40 min, 1 d and 3 d after operation;RASS scores were measured at the time of anesthesia emergence, 5 min ,15 min , and 30 min after anesthesia emergence;Extubation time;Full awake time;Use of vasoactive drugs during anesthesia;Postoperative patient and anesthesiologist satisfaction score;Other clinical adverse events; | — |
Countries
China
Contacts
Public ContactYong Wu
Lianyungang Clinical Medical College of Nanjing Medical University
Outcome results
None listed